I would have to say no. My eyes aren't as yellow as they used to be, but there is still a trace of jaundice with them. Sickle cell works more on the blood cells themselves then on the liver or spleen. Perhaps hydrating might help, after all, jaundiced cells are just broken down dead cells that the body has had a hard time excreting. So if you hydrate, it might help flush some of it out...just a thought.
I don't know about that cayenne pepper remedy, sorry.